The most frequent tools are pelletizing positions and dies. Contact with certain chemicals can accelerate the corrosion process and contaminate an entire production. Since powders are generally very fine, there is a need for tools with high hardness in order to resist abrasive wear. Another fundamental property is the compressive strength, if nothing else fails the fatigue determines the end of life of the tool and this property will have to be guarantee for millions of cycles. Given they are productions of very long series, we can also obtain seizing and adhesive wear. Given the sensitive nature of the medicines, sometimes the coating of the tools may not be the solution.